2btf

From Proteopedia

THE STRUCTURE OF CRYSTALLINE PROFILIN-BETA-ACTIN

Structural highlights

2btf is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.55Å
Ligands:	ACE, ATP, HIC, SR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACTB_BOVIN Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The three-dimensional structure of bovine profilin-beta-actin has been solved to 2.55 A resolution by X-ray crystallography. There are several significant local changes in the structure of beta-actin compared with alpha-actin as well as an overall 5 degrees rotation between its two major domains. Actin molecules in the crystal are organized into ribbons through intermolecular contacts like those found in oligomeric protein assemblies. Profilin forms two extensive contacts with the actin ribbon, one of which appears to correspond to the solution contact in vitro.

The structure of crystalline profilin-beta-actin.,Schutt CE, Myslik JC, Rozycki MD, Goonesekere NC, Lindberg U Nature. 1993 Oct 28;365(6449):810-6. PMID:8413665^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

85 reviews cite this structure

Molecular mechanisms controlling actin filament dynamics in nonmuscle cells.

Pollard et al. (2000)

84 more

290 other articles

No citations found

References

↑ Schutt CE, Myslik JC, Rozycki MD, Goonesekere NC, Lindberg U. The structure of crystalline profilin-beta-actin. Nature. 1993 Oct 28;365(6449):810-6. PMID:8413665 doi:http://dx.doi.org/10.1038/365810a0

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

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PDB ID 2btf

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2btf

From Proteopedia

THE STRUCTURE OF CRYSTALLINE PROFILIN-BETA-ACTIN

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

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