2bvr

From Proteopedia

Human thrombin complexed with fragment-based small molecules occupying the S1 pocket

Structural highlights

2bvr is a 3 chain structure with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.25Å
Ligands:	4CP, TYS
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HIRV2_HIRME Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen.

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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PDB ID 2bvr

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2bvr

From Proteopedia

Human thrombin complexed with fragment-based small molecules occupying the S1 pocket

Structural highlights

Function

Evolutionary Conservation

See Also

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