2bwj

Structural highlights

Function

KAD5_HUMAN Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.^{[1] [2]}

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Adenylate kinase 3D structures

References

1. ↑ Solaroli N, Panayiotou C, Johansson M, Karlsson A. Identification of two active functional domains of human adenylate kinase 5. FEBS Lett. 2009 Sep 3;583(17):2872-6. PMID:19647735 doi:10.1016/j.febslet.2009.07.047
2. ↑ Amiri M, Conserva F, Panayiotou C, Karlsson A, Solaroli N. The human adenylate kinase 9 is a nucleoside mono Int J Biochem Cell Biol. 2013 May;45(5):925-31. PMID:23416111 doi:10.1016/j.biocel.2013.02.004