2d58

Structural highlights

Function

AIF1_HUMAN Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.^{[1] [2] [3]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Chen X, Kelemen SE, Autieri MV. AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF. Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1217-22. Epub 2004 Apr 29. PMID:15117732 doi:http://dx.doi.org/10.1161/01.ATV.0000130024.50058.de
2. ↑ Kelemen SE, Autieri MV. Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies. Am J Pathol. 2005 Aug;167(2):619-26. PMID:16049345 doi:http://dx.doi.org/10.1016/S0002-9440(10)63003-9
3. ↑ Schulze JO, Quedenau C, Roske Y, Adam T, Schuler H, Behlke J, Turnbull AP, Sievert V, Scheich C, Mueller U, Heinemann U, Bussow K. Structural and functional characterization of human Iba proteins. FEBS J. 2008 Sep;275(18):4627-40. Epub 2008 Aug 11. PMID:18699778 doi:10.1111/j.1742-4658.2008.06605.x