2dlc

From Proteopedia

Jump to: navigation, search

Crystal structure of the ternary complex of yeast tyrosyl-tRNA synthetase

Structural highlights

2dlc is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:1MA, 2MG, 5MC, 5MU, 6IA, H2U, M2G, MG, OMG, PSU, YMP
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SYYC_YEAST Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). The specificity determinants on tRNA(Tyr) are the base pair C1-G72, the discriminator residue A73, and the three anticodon bases G34, U35 and A36. Also involved in nuclear tRNA export.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Sarkar S, Azad AK, Hopper AK. Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14366-71. PMID:10588711
  2. ↑ Fechter P, Rudinger-Thirion J, Theobald-Dietrich A, Giege R. Identity of tRNA for yeast tyrosyl-tRNA synthetase: tyrosylation is more sensitive to identity nucleotides than to structural features. Biochemistry. 2000 Feb 22;39(7):1725-33. PMID:10677221

Contents


PDB ID 2dlc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/2dlc"
Personal tools