2eo0

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Crystal Structure of Holliday Junction Resolvase ST1444

Structural highlights

2eo0 is a 2 chain structure with sequence from Sulfurisphaera tokodaii str. 7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

HJC_SULTO A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Inhibits the helicase activity of Hel308 (Hjm).[HAMAP-Rule:MF_01490][1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Li Z, Lu S, Hou G, Ma X, Sheng D, Ni J, Shen Y. Hjm/Hel308A DNA helicase from Sulfolobus tokodaii promotes replication fork regression and interacts with Hjc endonuclease in vitro. J Bacteriol. 2008 Apr;190(8):3006-17. PMID:18296528 doi:10.1128/JB.01662-07

Contents


PDB ID 2eo0

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OCA

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