4v50

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Crystal Structure of Ribosome with messenger RNA and the Anticodon stem-loop of P-site tRNA.

Structural highlights

4v50 is a 20 chain structure with sequence from Escherichia coli. This structure supersedes the now removed PDB entries 2i2p, 2i2t, 2i2u and 2i2v. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.22Å
Ligands:MG, ZN
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RL27_ECOLI

Publication Abstract from PubMed

Protein synthesis requires the accurate positioning of mRNA and tRNA in the peptidyl-tRNA site of the ribosome. Here we describe x-ray crystal structures of the intact bacterial ribosome from Escherichia coli in a complex with mRNA and the anticodon stem-loop of P-site tRNA. At 3.5-A resolution, these structures reveal rearrangements in the intact ribosome that clamp P-site tRNA and mRNA on the small ribosomal subunit. Binding of the anticodon stem-loop of P-site tRNA to the ribosome is sufficient to lock the head of the small ribosomal subunit in a single conformation, thereby preventing movement of mRNA and tRNA before mRNA decoding.

Structural basis for mRNA and tRNA positioning on the ribosome.,Berk V, Zhang W, Pai RD, Cate JH Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15830-4. Epub 2006 Oct 12. PMID:17038497[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
23 reviews cite this structure
A structural understanding of the dynamic ribosome machine.
Steitz et al. (2008)
22 more
101 other articles
No citations found

See Also

References

  1. ↑ Berk V, Zhang W, Pai RD, Cate JH. Structural basis for mRNA and tRNA positioning on the ribosome. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15830-4. Epub 2006 Oct 12. PMID:17038497

Contents


PDB ID 4v50

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OCA

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