2ie4

From Proteopedia

Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid

Structural highlights

2ie4 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.6Å
Ligands:	MN, OKA
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

2AAA_HUMAN The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.^[1]

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Tang Z, Shu H, Qi W, Mahmood NA, Mumby MC, Yu H. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell. 2006 May;10(5):575-85. Epub 2006 Mar 30. PMID:16580887 doi:10.1016/j.devcel.2006.03.010

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 See Also
5 References

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PDB ID 2ie4

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2ie4

From Proteopedia

Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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