2jr7
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proteopedia linkSolution structure of human DESR1
Structural highlights
Function[DPH3_HUMAN] Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (By similarity).[1] [2] Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.[3] [4] Evolutionary ConservationCheck, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
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Categories: Human | Large Structures | Shi, Y | Wu, F | Wu, J | Csl zinc finger | Desr1 | Metal binding protein