Structural highlights
Function
CUL9_HUMAN Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).[1] [2] [3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Nikolaev AY, Li M, Puskas N, Qin J, Gu W. Parc: a cytoplasmic anchor for p53. Cell. 2003 Jan 10;112(1):29-40. PMID:12526791
- ↑ Skaar JR, Florens L, Tsutsumi T, Arai T, Tron A, Swanson SK, Washburn MP, DeCaprio JA. PARC and CUL7 form atypical cullin RING ligase complexes. Cancer Res. 2007 Mar 1;67(5):2006-14. PMID:17332328 doi:67/5/2006
- ↑ Li Z, Pei XH, Yan J, Yan F, Cappell KM, Whitehurst AW, Xiong Y. CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. Mol Cell. 2014 Jun 5;54(5):805-19. doi: 10.1016/j.molcel.2014.03.046. Epub 2014, May 1. PMID:24793696 doi:http://dx.doi.org/10.1016/j.molcel.2014.03.046
