2kki

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Solution structure of human Interleukin 1a

Structural highlights

2kki is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IL1A_HUMAN Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

As part of our NMR structure determination of the human Interleukin-1alpha, we report nearly complete NMR chemical shift assignments for the (1)H, (13)C and (15)N nuclei.

1H, 13C and 15N backbone and side chain resonance assignments of human interleukin 1alpha.,Chang HK, Mohan SK, Chin Y Biomol NMR Assign. 2010 Apr;4(1):59-60. Epub 2010 Jan 28. PMID:20108067[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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See Also

References

  1. ↑ Chang HK, Mohan SK, Chin Y. 1H, 13C and 15N backbone and side chain resonance assignments of human interleukin 1alpha. Biomol NMR Assign. 2010 Apr;4(1):59-60. Epub 2010 Jan 28. PMID:20108067 doi:10.1007/s12104-010-9207-z

Contents


PDB ID 2kki

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