2l0j

From Proteopedia

Jump to: navigation, search

Solid State NMR structure of the M2 proton channel from Influenza A Virus in hydrated lipid bilayer

Structural highlights

2l0j is a 4 chain structure with sequence from Influenza A virus (A/Udorn/307/1972(H3N2)). Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solid-state NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

M2_I72A2 Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[1]

See Also

References

  1. ↑ Holsinger LJ, Nichani D, Pinto LH, Lamb RA. Influenza A virus M2 ion channel protein: a structure-function analysis. J Virol. 1994 Mar;68(3):1551-63. PMID:7508997

Contents


PDB ID 2l0j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/2l0j"
Personal tools