2mdk

From Proteopedia

NMR Solution Structure of MSP-P56S Domain/VAPB in DPC

Structural highlights

2mdk is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

VAPB_HUMAN Adult-onset proximal spinal muscular atrophy, autosomal dominant;Amyotrophic lateral sclerosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

VAPB_HUMAN Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.^[1] ^[2] ^[3]

References

↑ Kanekura K, Nishimoto I, Aiso S, Matsuoka M. Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8). J Biol Chem. 2006 Oct 6;281(40):30223-33. Epub 2006 Aug 4. PMID:16891305 doi:http://dx.doi.org/10.1074/jbc.M605049200
↑ Chen HJ, Anagnostou G, Chai A, Withers J, Morris A, Adhikaree J, Pennetta G, de Belleroche JS. Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis. J Biol Chem. 2010 Dec 17;285(51):40266-81. doi: 10.1074/jbc.M110.161398. Epub, 2010 Oct 12. PMID:20940299 doi:http://dx.doi.org/10.1074/jbc.M110.161398
↑ De Vos KJ, Morotz GM, Stoica R, Tudor EL, Lau KF, Ackerley S, Warley A, Shaw CE, Miller CC. VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. Hum Mol Genet. 2012 Mar 15;21(6):1299-311. doi: 10.1093/hmg/ddr559. Epub 2011 Nov, 30. PMID:22131369 doi:http://dx.doi.org/10.1093/hmg/ddr559

1 Structural highlights
2 Disease
3 Function
4 See Also
5 References

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PDB ID 2mdk

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Categories: Homo sapiens | Large Structures | Lim L | Qin H | Song J

2mdk

From Proteopedia

NMR Solution Structure of MSP-P56S Domain/VAPB in DPC

Structural highlights

Disease

Function

See Also

References

Contents

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