2moc

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Membrane induced structure of novel human tachykinin Hemokinin-1 (hHK1)

Structural highlights

2moc is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TKN4_HUMAN Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.[1] [2] [3] [4]

References

  1. ↑ Page NM, Bell NJ, Gardiner SM, Manyonda IT, Brayley KJ, Strange PG, Lowry PJ. Characterization of the endokinins: human tachykinins with cardiovascular activity. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6245-50. Epub 2003 Apr 25. PMID:12716968 doi:http://dx.doi.org/10.1073/pnas.0931458100
  2. ↑ Yoshioka D, Takebuchi F, Nishimori T, Naono R, Ikeda T, Nakayama T. Intrathecal administration of the common carboxyl-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat. Neurosci Lett. 2006 Dec 27;410(3):193-7. Epub 2006 Nov 13. PMID:17101218 doi:http://dx.doi.org/10.1016/j.neulet.2006.09.024
  3. ↑ Ravina CG, Seda M, Pinto FM, Orea A, Fernandez-Sanchez M, Pintado CO, Candenas ML. A role for tachykinins in the regulation of human sperm motility. Hum Reprod. 2007 Jun;22(6):1617-25. Epub 2007 Apr 16. PMID:17437961 doi:http://dx.doi.org/dem069
  4. ↑ Naono R, Nakayama T, Ikeda T, Matsushima O, Nishimori T. Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. Brain Res. 2007 Aug 24;1165:71-80. Epub 2007 Jul 3. PMID:17655832 doi:http://dx.doi.org/S0006-8993(07)01265-6

Contents


PDB ID 2moc

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OCA

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