2phw

From Proteopedia

Pterocarpus angolensis lectin (PAL) in complex with Man-9

Structural highlights

2phw is a 2 chain structure with sequence from Pterocarpus angolensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:	BMA, CA, MAN, MN, PCA, PRD_900112
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8GSD2_PTEAG

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of Pterocarpus angolensis seed lectin is presented in complex with a series of high mannose (Man) oligosaccharides ranging from Man-5 to Man-9. Despite that several of the nine Man residues of Man-9 have the potential to bind in the monosaccharide-binding site, all oligomannoses are bound in the same unique way, employing the tetrasaccharide sequence Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-. Isothermal titration calorimetry titration experiments using Man-5, Man-9, and the Man-9-containing glycoprotein soybean (Glycine max) agglutinin as ligands confirm the monovalence of Man-9 and show a 4-times higher affinity for Man-9 when it is presented to P. angolensis seed lectin in a glycoprotein context.

How a plant lectin recognizes high mannose oligosaccharides.,Garcia-Pino A, Buts L, Wyns L, Imberty A, Loris R Plant Physiol. 2007 Aug;144(4):1733-41. Epub 2007 Jun 7. PMID:17556509^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

4 reviews cite this structure

The repertoire of glycan determinants in the human glycome.

Cummings et al. (2009)

3 more

7 other articles

No citations found

References

↑ Garcia-Pino A, Buts L, Wyns L, Imberty A, Loris R. How a plant lectin recognizes high mannose oligosaccharides. Plant Physiol. 2007 Aug;144(4):1733-41. Epub 2007 Jun 7. PMID:17556509 doi:10.1104/pp.107.100867

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

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PDB ID 2phw

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2phw

From Proteopedia

Pterocarpus angolensis lectin (PAL) in complex with Man-9

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

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