2rkc

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Crystal structure of the measles virus hemagglutinin

Structural highlights

2rkc is a 1 chain structure with sequence from Measles morbillivirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:NAG
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HEMA_MEASE Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.[1]

See Also

References

  1. ↑ Galbraith SE, Tiwari A, Baron MD, Lund BT, Barrett T, Cosby SL. Morbillivirus downregulation of CD46. J Virol. 1998 Dec;72(12):10292-7. PMID:9811778

Contents


PDB ID 2rkc

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OCA

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