2rqf

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Solution structure of juvenile hormone binding protein from silkworm in complex with JH III

Structural highlights

2rqf is a 1 chain structure with sequence from Bombyx mori. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 20 models
Ligands:JH3
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q9U556_BOMMO

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Juvenile hormone (JH) plays crucial roles in many aspects of the insect life. All the JH actions are initiated by transport of JH in the hemolymph as a complex with JH-binding protein (JHBP) to target tissues. Here, we report structural mechanism of JH delivery by JHBP based upon the crystal and solution structures of apo and JH-bound JHBP. In solution, apo-JHBP exists in equilibrium of multiple conformations with different orientations of the gate helix for the hormone-binding pocket ranging from closed to open forms. JH-binding to the gate-open form results in the fully closed JHBP-JH complex structure where the bound JH is completely buried inside the protein. JH-bound JHBP opens the gate helix to release the bound hormone likely by sensing the less polar environment at the membrane surface of target cells. This is the first report that provides structural insight into JH signaling.

Structural mechanism of JH delivery in hemolymph by JHBP of silkworm, Bombyx mori.,Suzuki R, Fujimoto Z, Shiotsuki T, Tsuchiya W, Momma M, Tase A, Miyazawa M, Yamazaki T Sci Rep. 2011;1:133. doi: 10.1038/srep00133. Epub 2011 Oct 28. PMID:22355650[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
3 reviews cite this structure
Tubular lipid binding proteins (TULIPs) growing everywhere.
Wong et al. (2017)
2 more
26 other articles
No citations found

References

  1. ↑ Suzuki R, Fujimoto Z, Shiotsuki T, Tsuchiya W, Momma M, Tase A, Miyazawa M, Yamazaki T. Structural mechanism of JH delivery in hemolymph by JHBP of silkworm, Bombyx mori. Sci Rep. 2011;1:133. doi: 10.1038/srep00133. Epub 2011 Oct 28. PMID:22355650 doi:10.1038/srep00133

Contents


PDB ID 2rqf

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