2vsw

Structural highlights

Function

DUS16_HUMAN Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Dual specificity phosphatase 3D structures
• MAP kinase phosphatase

References

1. ↑ Masuda K, Shima H, Watanabe M, Kikuchi K. MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein. J Biol Chem. 2001 Oct 19;276(42):39002-11. Epub 2001 Aug 6. PMID:11489891 doi:http://dx.doi.org/10.1074/jbc.M104600200
2. ↑ Willoughby EA, Collins MK. Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2. J Biol Chem. 2005 Jul 8;280(27):25651-8. Epub 2005 May 10. PMID:15888437 doi:http://dx.doi.org/10.1074/jbc.M501926200