2vwi

From Proteopedia

Jump to: navigation, search

Structure of the OSR1 kinase, a hypertension drug target

Structural highlights

2vwi is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.15Å
Ligands:ANP, AU, MG
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OXSR1_HUMAN Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Chen W, Yazicioglu M, Cobb MH. Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. J Biol Chem. 2004 Mar 19;279(12):11129-36. Epub 2004 Jan 5. PMID:14707132 doi:10.1074/jbc.M313562200

Contents


PDB ID 2vwi

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools