2wzi

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BtGH84 D243N in complex with 5F-oxazoline

Structural highlights

2wzi is a 2 chain structure with sequence from Bacteroides thetaiotaomicron VPI-5482. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:5FN, CA, GOL, NA
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OGA_BACTN Biological function unknown. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

N-Acetylglucosamine beta-O-linked to serine and threonine residues of nucleocytoplasmic proteins (O-GlcNAc) has been linked to neurodegeneration, cellular stress response, and transcriptional regulation. Removal of O-GlcNAc is catalyzed by O-GlcNAcase (OGA) using a substrate-assisted catalytic mechanism. Here we define the reaction coordinate using chemical approaches and directly observe both a Michaelis complex and the oxazoline intermediate.

Visualizing the Reaction Coordinate of an O-GlcNAc Hydrolase.,He Y, Macauley MS, Stubbs KA, Vocadlo DJ, Davies GJ J Am Chem Soc. 2010 Jan 12. PMID:20067256[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
13 reviews cite this structure
O-GlcNAc signalling: implications for cancer cell biology.
Slawson et al. (2011)
12 more
30 other articles
No citations found

See Also

References

  1. ↑ He Y, Macauley MS, Stubbs KA, Vocadlo DJ, Davies GJ. Visualizing the Reaction Coordinate of an O-GlcNAc Hydrolase. J Am Chem Soc. 2010 Jan 12. PMID:20067256 doi:10.1021/ja9086769

Contents


PDB ID 2wzi

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OCA

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