3a4c

Structural highlights

Function

CDT1_MOUSE Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.^{[1] [2] [3]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Arentson E, Faloon P, Seo J, Moon E, Studts JM, Fremont DH, Choi K. Oncogenic potential of the DNA replication licensing protein CDT1. Oncogene. 2002 Feb 14;21(8):1150-8. PMID:11850834 doi:http://dx.doi.org/10.1038/sj.onc.1205175
2. ↑ Yanagi K, Mizuno T, You Z, Hanaoka F. Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. J Biol Chem. 2002 Oct 25;277(43):40871-80. Epub 2002 Aug 20. PMID:12192004 doi:http://dx.doi.org/10.1074/jbc.M206202200
3. ↑ Sugimoto N, Tatsumi Y, Tsurumi T, Matsukage A, Kiyono T, Nishitani H, Fujita M. Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. J Biol Chem. 2004 May 7;279(19):19691-7. Epub 2004 Mar 1. PMID:14993212 doi:10.1074/jbc.M313175200