3avs

From Proteopedia

Catalytic fragment of UTX/KDM6A bound with N-oxyalylglycine, and Ni(II)

Structural highlights

3avs is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.85Å
Ligands:	CL, EDO, NI, OGA, ZN
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

KDM6A_HUMAN Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

KDM6A_HUMAN Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.^[1] ^[2]

References

↑ Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007 Oct 11;449(7163):689-94. Epub 2007 Sep 12. PMID:17851529 doi:http://dx.doi.org/10.1038/nature06192
↑ Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R. Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science. 2007 Oct 19;318(5849):447-50. Epub 2007 Aug 30. PMID:17761849 doi:http://dx.doi.org/1149042

1 Structural highlights
2 Disease
3 Function
4 See Also
5 References

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PDB ID 3avs

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Categories: Homo sapiens | Large Structures | Sengoku T | Yokoyama S

3avs

From Proteopedia

Catalytic fragment of UTX/KDM6A bound with N-oxyalylglycine, and Ni(II)

Structural highlights

Disease

Function

See Also

References

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