3eat

Structural highlights

Function

PVCB_PSEAE Involved in the biosynthesis of paerucumarin, a cyclized isocyano derivative of tyrosine (PubMed:18689486, PubMed:18824174). Catalyzes the 2-oxoglutarate-dependent oxidation of tyrosine isonitrile (PubMed:25866990).^{[1] [2] [3]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Clarke-Pearson MF, Brady SF. Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa. J Bacteriol. 2008 Oct;190(20):6927-30. PMID:18689486 doi:10.1128/JB.00801-08
2. ↑ Drake EJ, Gulick AM. Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin. J Mol Biol. 2008 Dec 5;384(1):193-205. Epub 2008 Sep 19. PMID:18824174 doi:10.1016/j.jmb.2008.09.027
3. ↑ Zhu J, Lippa GM, Gulick AM, Tipton PA. Examining Reaction Specificity in PvcB, a Source of Diversity in Isonitrile-Containing Natural Products. Biochemistry. 2015 Apr 28;54(16):2659-69. doi: 10.1021/acs.biochem.5b00255. Epub , 2015 Apr 20. PMID:25866990 doi:http://dx.doi.org/10.1021/acs.biochem.5b00255