3g1p

Structural highlights

Function

PHNP_ECOLI Catalyzes the hydrolysis of the cyclic ribose-phosphate to form alpha-D-ribose 1,5-bisphosphate.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Hove-Jensen B, McSorley FR, Zechel DL. Physiological role of phnP-specified phosphoribosyl cyclic phosphodiesterase in catabolism of organophosphonic acids by the carbon-phosphorus lyase pathway. J Am Chem Soc. 2011 Mar 16;133(10):3617-24. doi: 10.1021/ja1102713. Epub 2011 Feb, 22. PMID:21341651 doi:10.1021/ja1102713
2. ↑ Podzelinska K, He SM, Wathier M, Yakunin A, Proudfoot M, Hove-Jensen B, Zechel DL, Jia Z. Structure of PhnP, a phosphodiesterase of the carbon-phosphorus lyase pathway for phosphonate degradation. J Biol Chem. 2009 Jun 19;284(25):17216-26. Epub 2009 Apr 14. PMID:19366688 doi:10.1074/jbc.M808392200