3ggz

Structural highlights

Function

IST1_YEAST Involved in a late step in sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins are targeted into the vacuole after fusion of the endosome with the vacuole. Regulates the recruitment of VPS4 to the ESCRT-III complex, probably in conjunction with DID2, and VPS4 catalyzes the disassembly of the ESCRT-III complex.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Increased sodium tolerance protein
• Vacuolar protein sorting-associated protein 3D structures

References

1. ↑ Dimaano C, Jones CB, Hanono A, Curtiss M, Babst M. Ist1 regulates Vps4 localization and assembly. Mol Biol Cell. 2008 Feb;19(2):465-74. Epub 2007 Nov 21. PMID:18032582 doi:http://dx.doi.org/E07-08-0747
2. ↑ Rue SM, Mattei S, Saksena S, Emr SD. Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting. Mol Biol Cell. 2008 Feb;19(2):475-84. Epub 2007 Nov 21. PMID:18032584 doi:http://dx.doi.org/E07-07-0694