3haq

From Proteopedia

Crystal structure of bacteriorhodopsin mutant I148A crystallized from bicelles

Structural highlights

3haq is a 1 chain structure with sequence from Halobacterium salinarum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.3Å
Ligands:	CPS, D10, D12, DD9, HP6, R16, RET
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BACR_HALSA Light-driven proton pump.

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

A major driving force for water-soluble protein folding is the hydrophobic effect, but membrane proteins cannot make use of this stabilizing contribution in the apolar core of the bilayer. It has been proposed that membrane proteins compensate by packing more efficiently. We therefore investigated packing contributions experimentally by observing the energetic and structural consequences of cavity creating mutations in the core of a membrane protein. We observed little difference in the packing energetics of water and membrane soluble proteins. Our results imply that other mechanisms are employed to stabilize the structure of membrane proteins.

Similar energetic contributions of packing in the core of membrane and water-soluble proteins.,Joh NH, Oberai A, Yang D, Whitelegge JP, Bowie JU J Am Chem Soc. 2009 Aug 12;131(31):10846-7. PMID:19603754^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

13 reviews cite this structure

Lessons from the lysozyme of phage T4.

Baase et al. (2010)

12 more

32 other articles

No citations found

References

↑ Joh NH, Oberai A, Yang D, Whitelegge JP, Bowie JU. Similar energetic contributions of packing in the core of membrane and water-soluble proteins. J Am Chem Soc. 2009 Aug 12;131(31):10846-7. PMID:19603754 doi:10.1021/ja904711k

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

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PDB ID 3haq

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Categories: Halobacterium salinarum | Large Structures | Bowie JU | Joh NH | Yang D

3haq

From Proteopedia

Crystal structure of bacteriorhodopsin mutant I148A crystallized from bicelles

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

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