3ho8

Structural highlights

Function

PYC_STAAM Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Pyruvate carboxylase 3D structures

References

1. ↑ Yu LP, Xiang S, Lasso G, Gil D, Valle M, Tong L. A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure. 2009 Jun 10;17(6):823-32. PMID:19523900 doi:10.1016/j.str.2009.04.008
2. ↑ Yu LP, Chou CY, Choi PH, Tong L. Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis. Biochemistry. 2013 Jan 9. PMID:23286247 doi:http://dx.doi.org/10.1021/bi301294d