Structural highlights
Function
CAPSD_SIRV2 Self-assembles to form a helical, filamentous nucleocapsid (PubMed:25999507). The capsid proteins wrap around the DNA and maintain it in an A-form by non-specific desolvation and specific coordination of the DNA phosphate groups by positively charged residues (Probable) (PubMed:25999507). This certainly protects the viral DNA under conditions such as the extreme desiccation of its host (Probable).[1] [2] [3]
See Also
References
- ↑ DiMaio F, Yu X, Rensen E, Krupovic M, Prangishvili D, Egelman EH. Virology. A virus that infects a hyperthermophile encapsidates A-form DNA. Science. 2015 May 22;348(6237):914-7. doi: 10.1126/science.aaa4181. PMID:25999507 doi:http://dx.doi.org/10.1126/science.aaa4181
- ↑ DiMaio F, Yu X, Rensen E, Krupovic M, Prangishvili D, Egelman EH. Virology. A virus that infects a hyperthermophile encapsidates A-form DNA. Science. 2015 May 22;348(6237):914-7. doi: 10.1126/science.aaa4181. PMID:25999507 doi:http://dx.doi.org/10.1126/science.aaa4181
- ↑ Wang F, Baquero DP, Beltran LC, Su Z, Osinski T, Zheng W, Prangishvili D, Krupovic M, Egelman EH. Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):19643-19652. PMID:32759221 doi:10.1073/pnas.2011125117