3n71

Structural highlights

Function

SMYD1_MOUSE Methylates histone H3 at 'Lys-4' (H3K4me). Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.^{[1] [2]}

See Also

• Histone methyltransferase 3D structures

References

1. ↑ Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet. 2002 May;31(1):25-32. Epub 2002 Apr 1. PMID:11923873 doi:http://dx.doi.org/10.1038/ng866
2. ↑ Sirinupong N, Brunzelle J, Ye J, Pirzada A, Nico L, Yang Z. Crystal structure of cardiac specific histone methyltransferase SmyD1 reveals unusual active site architecture. J Biol Chem. 2010 Oct 12. PMID:20943667 doi:10.1074/jbc.M110.168187