3n9z

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Crystal structure of human CYP11A1 in complex with 22-hydroxycholesterol

Structural highlights

3n9z is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.17Å
Ligands:FES, HC9, HEM
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

CP11A_HUMAN Inherited isolated adrenal insufficiency due to CYP11A1 deficiency;46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.

Function

CP11A_HUMAN Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.[1]

See Also

References

  1. ↑ Strushkevich N, Mackenzie F, Cherkesova T, Grabovec I, Usanov S, Park HW. Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. Proc Natl Acad Sci U S A. 2011 Jun 2. PMID:21636783 doi:10.1073/pnas.1019441108

Contents


PDB ID 3n9z

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OCA

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