3p5j

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The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease

Structural highlights

3p5j is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RNH2A_MOUSE Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.[1]

See Also

References

  1. ↑ Shaban NM, Harvey S, Perrino FW, Hollis T. The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction. J Biol Chem. 2010 Feb 5;285(6):3617-24. Epub 2009 Nov 18. PMID:19923215 doi:10.1074/jbc.M109.059048

Contents


PDB ID 3p5j

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OCA

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