3p9a

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An atomic view of the nonameric small terminase subunit of Bacteriophage P22

Structural highlights

3p9a is a 9 chain structure with sequence from Salmonella virus P22. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.755Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TERS_BPP22 The terminase small subunit binds to the packaging initiation site and regulates the ATPase activity of the terminase large subunit. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer once the capsid is full (headful packaging). Once the capsid is packaged with the DNA, the terminase complex is substituted by neck proteins.[1]

See Also

References

  1. ↑ Nemecek D, Lander GC, Johnson JE, Casjens SR, Thomas GJ Jr. Assembly architecture and DNA binding of the bacteriophage P22 terminase small subunit. J Mol Biol. 2008 Nov 14;383(3):494-501. PMID:18775728 doi:10.1016/j.jmb.2008.08.050

Contents


PDB ID 3p9a

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OCA

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