3pn1

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Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo

Structural highlights

3pn1 is a 1 chain structure with sequence from Haemophilus influenzae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:IVH, IWH
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DNLJ_HAEIN DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).

See Also

Contents


PDB ID 3pn1

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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