3rcz

Structural highlights

Function

RAD60_SCHPO Required for repair of DNA double strand breaks which occur during replication, or induced by UV or gamma radiation, via recombination between sister chromatids. This has a subsequent role in the maintenance of chromosome structure. May work in conjunction with the Smc5-Smc6 complex.^{[1] [2]}

See Also

• SUMO conjugating enzyme Ubc9

References

1. ↑ Morishita T, Tsutsui Y, Iwasaki H, Shinagawa H. The Schizosaccharomyces pombe rad60 gene is essential for repairing double-strand DNA breaks spontaneously occurring during replication and induced by DNA-damaging agents. Mol Cell Biol. 2002 May;22(10):3537-48. PMID:11971984
2. ↑ Boddy MN, Shanahan P, McDonald WH, Lopez-Girona A, Noguchi E, Yates III JR, Russell P. Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Mol Cell Biol. 2003 Aug;23(16):5939-46. PMID:12897162