3sr4

From Proteopedia

Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor

Structural highlights

3sr4 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.5Å
Ligands:	ACT, GOL, SO4, TT8
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DOT1L_HUMAN Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

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PDB ID 3sr4

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3sr4

From Proteopedia

Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor

Structural highlights

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