3tvx

From Proteopedia

The structure of PDE4A with pentoxifylline at 2.84A resolution

Structural highlights

3tvx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.84Å
Ligands:	MG, PNX, SO4, ZN
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDE4A_HUMAN Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.^[1] ^[2]

References

↑ Lario PI, Bobechko B, Bateman K, Kelly J, Vrielink A, Huang Z. Purification and characterization of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells. Arch Biochem Biophys. 2001 Oct 1;394(1):54-60. PMID:11566027 doi:http://dx.doi.org/10.1006/abbi.2001.2513
↑ Wang H, Peng MS, Chen Y, Geng J, Robinson H, Houslay MD, Cai J, Ke H. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem J. 2007 Dec 1;408(2):193-201. PMID:17727341 doi:http://dx.doi.org/10.1042/BJ20070970

1 Structural highlights
2 Function
3 See Also
4 References

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PDB ID 3tvx

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Categories: Homo sapiens | Large Structures | Badger J | Sridhar V

3tvx

From Proteopedia

The structure of PDE4A with pentoxifylline at 2.84A resolution

Structural highlights

Function

See Also

References

Contents

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