3v5q

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Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models

Structural highlights

3v5q is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2001Å
Ligands:0F4, CL
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NTRK3_HUMAN Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.

See Also

Contents


PDB ID 3v5q

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OCA

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