3w4y

Structural highlights

Function

ERV1_YEAST FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS). Forms a redox cycle with MIA40 that involves a disulfide relay system. Important for maintaining the cysteine residues in MIA40 in an oxidized state. Reduced ERV1 is reoxidized by cytochrome c. Required for the maturation of cytoplasmic, but not of mitochondrial Fe/S proteins.[PROSITE-ProRule:PRU00654]^{[1] [2] [3] [4] [5] [6]}

See Also

• Sulfhydryl oxidase 3D structures

References

1. ↑ Lee J, Hofhaus G, Lisowsky T. Erv1p from Saccharomyces cerevisiae is a FAD-linked sulfhydryl oxidase. FEBS Lett. 2000 Jul 14;477(1-2):62-6. PMID:10899311
2. ↑ Lange H, Lisowsky T, Gerber J, Muhlenhoff U, Kispal G, Lill R. An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins. EMBO Rep. 2001 Aug;2(8):715-20. PMID:11493598 doi:http://dx.doi.org/10.1093/embo-reports/kve161
3. ↑ Hofhaus G, Lee JE, Tews I, Rosenberg B, Lisowsky T. The N-terminal cysteine pair of yeast sulfhydryl oxidase Erv1p is essential for in vivo activity and interacts with the primary redox centre. Eur J Biochem. 2003 Apr;270(7):1528-35. PMID:12654008
4. ↑ Mesecke N, Terziyska N, Kozany C, Baumann F, Neupert W, Hell K, Herrmann JM. A disulfide relay system in the intermembrane space of mitochondria that mediates protein import. Cell. 2005 Jul 1;121(7):1059-69. PMID:15989955 doi:http://dx.doi.org/S0092-8674(05)00357-0
5. ↑ Rissler M, Wiedemann N, Pfannschmidt S, Gabriel K, Guiard B, Pfanner N, Chacinska A. The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins. J Mol Biol. 2005 Oct 28;353(3):485-92. Epub 2005 Sep 8. PMID:16181637 doi:http://dx.doi.org/10.1016/j.jmb.2005.08.051
6. ↑ Allen S, Balabanidou V, Sideris DP, Lisowsky T, Tokatlidis K. Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c. J Mol Biol. 2005 Nov 11;353(5):937-44. Epub 2005 Sep 15. PMID:16185707 doi:http://dx.doi.org/S0022-2836(05)01003-X