3waf

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X-ray structure of apo-TtFbpA, a ferric ion-binding protein from thermus thermophilus HB8

Structural highlights

3waf is a 2 chain structure with sequence from Thermus thermophilus HB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:IPA
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q5SHV2_THET8

Publication Abstract from PubMed

Crystal structures of FbpA, the periplasmic ferric ion-binding protein of an iron-uptake ABC transporter, from Thermus thermophilus HB8 (TtFbpA) have been solved in apo and ferric ion-bound forms at 1.8 and 1.7 A resolution, respectively. The latter crystal structure shows that the bound ferric ion forms a novel six-coordinated complex with three tyrosine side chains, two bicarbonates and a water molecule in the metal-binding site. The results of gel-filtration chromatography and dynamic light scattering show that TtFbpA exists as a monomer in solution regardless of ferric ion binding and that TtFbpA adopts a more compact conformation in the ferric ion-bound state than in the apo state in solution.

A novel mode of ferric ion coordination by the periplasmic ferric ion-binding subunit FbpA of an ABC-type iron transporter from Thermus thermophilus HB8.,Wang S, Ogata M, Horita S, Ohtsuka J, Nagata K, Tanokura M Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):196-202. doi:, 10.1107/S1399004713026333. Epub 2013 Dec 31. PMID:24419392[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
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Structure of a Bacterial ABC Transporter Involved in the Import of an Acidic Polysaccharide Alginate.
Maruyama et al. (2015)
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See Also

References

  1. ↑ Wang S, Ogata M, Horita S, Ohtsuka J, Nagata K, Tanokura M. A novel mode of ferric ion coordination by the periplasmic ferric ion-binding subunit FbpA of an ABC-type iron transporter from Thermus thermophilus HB8. Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):196-202. doi:, 10.1107/S1399004713026333. Epub 2013 Dec 31. PMID:24419392 doi:http://dx.doi.org/10.1107/S1399004713026333

Contents


PDB ID 3waf

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OCA

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