4ahy
From Proteopedia
Flo5A cocrystallized with 3 mM GdAc3
Structural highlights
FunctionFLO5_YEAST Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose. Publication Abstract from PubMedProtein-bound contrast: The unusual observation of a heptanuclear gadolinium-oxo cluster on the surface of the cell-adhesion protein Flo5A establishes the basis for directed incorporation of poly-lanthanide clusters into biomolecules. The observed gadolinium cluster might serve as a paradigm for the design of protein-based MRI contrast agents. Complex Gadolinium-Oxo Clusters Formed along Concave Protein Surfaces.,Veelders M, Essen LO Chembiochem. 2012 Aug 31. doi: 10.1002/cbic.201200441. PMID:22936626[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
| ||||||||||||||||||||
