4da1

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Crystal structure of branched-chain alpha-ketoacid dehydrogenase phosphatase with Mg (II) ions at the active site

Structural highlights

4da1 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.383Å
Ligands:BME, MG
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

PPM1K_HUMAN Intermediate maple syrup urine disease.

Function

PPM1K_HUMAN Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.[1]

See Also

References

  1. Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y. A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. Genes Dev. 2007 Apr 1;21(7):784-96. Epub 2007 Mar 20. PMID:17374715 doi:http://dx.doi.org/10.1101/gad.1499107

Contents


PDB ID 4da1

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