4dag

Publication Abstract from PubMed

Human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. F is also a major target of the neutralizing antibody response. Here we show that a potently neutralizing anti-human metapneumovirus antibody (DS7) binds a structurally invariant domain of F, revealing a new epitope that could be targeted in vaccine development.

Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site.,Wen X, Krause JC, Leser GP, Cox RG, Lamb RA, Williams JV, Crowe JE Jr, Jardetzky TS Nat Struct Mol Biol. 2012 Mar 4. doi: 10.1038/nsmb.2250. PMID:22388735^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.