4e08

Structural highlights

Function

DJ1B_DROME Plays an important role in cell protection against oxidative stress and cell death by acting as a oxidative stress sensor (PubMed:16139214, PubMed:16203113, PubMed:16894167, PubMed:20457924). Does not play a role in methylglyoxal detoxification (PubMed:27903648). Plays a role in mitochondrial function together with Pink1 (PubMed:20457924). In motor neurons regulates structural synaptic plasticity of locomotor behavior as part of the PTEN-phosphatidylinositol 3-kinase pathway in response to oxygen species (ROS) levels (PubMed:30540251).^{[1] [2] [3] [4] [5] [6]}

See Also

• Protein DJ-1

References

1. ↑ Menzies FM, Yenisetti SC, Min KT. Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Curr Biol. 2005 Sep 6;15(17):1578-82. doi: 10.1016/j.cub.2005.07.036. PMID:16139214 doi:http://dx.doi.org/10.1016/j.cub.2005.07.036
2. ↑ Park J, Kim SY, Cha GH, Lee SB, Kim S, Chung J. Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction. Gene. 2005 Nov 21;361:133-9. doi: 10.1016/j.gene.2005.06.040. Epub 2005 Oct 3. PMID:16203113 doi:http://dx.doi.org/10.1016/j.gene.2005.06.040
3. ↑ Meulener MC, Xu K, Thomson L, Ischiropoulos H, Bonini NM. Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12517-22. doi:, 10.1073/pnas.0601891103. Epub 2006 Aug 7. PMID:16894167 doi:http://dx.doi.org/10.1073/pnas.0601891103
4. ↑ Hao LY, Giasson BI, Bonini NM. DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9747-52. doi:, 10.1073/pnas.0911175107. Epub 2010 May 10. PMID:20457924 doi:http://dx.doi.org/10.1073/pnas.0911175107
5. ↑ Pfaff DH, Fleming T, Nawroth P, Teleman AA. Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification. J Biol Chem. 2017 Jan 13;292(2):685-690. doi: 10.1074/jbc.M116.743823. Epub 2016 , Nov 30. PMID:27903648 doi:http://dx.doi.org/10.1074/jbc.M116.743823
6. ↑ Oswald MC, Brooks PS, Zwart MF, Mukherjee A, West RJ, Giachello CN, Morarach K, Baines RA, Sweeney ST, Landgraf M. Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila. Elife. 2018 Dec 17;7. pii: 39393. doi: 10.7554/eLife.39393. PMID:30540251 doi:http://dx.doi.org/10.7554/eLife.39393