4f7u

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The 6S snRNP assembly intermediate

Structural highlights

4f7u is a 12 chain structure with sequence from Drosophila melanogaster, Mus musculus and Xenopus laevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.898Å
Ligands:P6G
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SMD1_MOUSE Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA (By similarity).

See Also

Contents


PDB ID 4f7u

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OCA

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