4hlz

From Proteopedia

Jump to: navigation, search

Crystal Structure of Fab C179 in Complex with a H2N2 influenza virus hemagglutinin

Structural highlights

4hlz is a 12 chain structure with sequence from Influenza A virus (A/Japan/305/1957(H2N2)) and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Ligands:BMA, EDO, MAN, NAG, SO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

C7S226_I57A0 Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]

Publication Abstract from PubMed

We report structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets a similar epitope on the HA stem as the recently identified human broadly neutralizing antibodies (bnAbs). C179 also inhibits the low-pH conformational change of the HA, but uses a different angle of approach and both heavy and light chains.

Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 hemagglutinin.,Dreyfus C, Ekiert DC, Wilson IA J Virol. 2013 Apr 3. PMID:23552413[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Loading citation details..
Citations
20 reviews cite this structure
Next-generation influenza vaccines: opportunities and challenges.
Wei et al. (2020)
19 more
49 other articles
No citations found

See Also

References

  1. ↑ Dreyfus C, Ekiert DC, Wilson IA. Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 hemagglutinin. J Virol. 2013 Apr 3. PMID:23552413 doi:10.1128/JVI.02975-12

Contents


PDB ID 4hlz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/4hlz"
Personal tools