4i9d

From Proteopedia

Jump to: navigation, search

X-ray structure of NikA in complex with Fe-N,N'-Bis(2-pyridylmethyl)-N-carboxymethyl-N'-methyl

Structural highlights

4i9d is a 2 chain structure with sequence from Ecobd. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:ACT, GOL, L4D, SO4
Gene:b3476, JW3441, nikA (ECOBD)
Activity:Nickel-transporting ATPase, with EC number 3.6.3.24
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[NIKA_ECOLI] Involved in a nickel transport system, probably represents the nickel binder.

Publication Abstract from PubMed

The substrate for an artificial iron monooxygenase was selected by using docking calculations. The high catalytic efficiency of the reported enzyme for sulfide oxidation was directly correlated to the predicted substrate binding mode in the protein cavity, thus illustrating the synergetic effect of the substrate binding site, protein scaffold, and catalytic site.

An artificial oxygenase built from scratch: substrate binding site identified using a docking approach.,Esmieu C, Cherrier MV, Amara P, Girgenti E, Marchi-Delapierre C, Oddon F, Iannello M, Jorge-Robin A, Cavazza C, Menage S Angew Chem Int Ed Engl. 2013 Apr 2;52(14):3922-5. doi: 10.1002/anie.201209021., Epub 2013 Feb 25. PMID:23440925[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Loading citation details..
Citations
No citations found

References

  1. Esmieu C, Cherrier MV, Amara P, Girgenti E, Marchi-Delapierre C, Oddon F, Iannello M, Jorge-Robin A, Cavazza C, Menage S. An artificial oxygenase built from scratch: substrate binding site identified using a docking approach. Angew Chem Int Ed Engl. 2013 Apr 2;52(14):3922-5. doi: 10.1002/anie.201209021., Epub 2013 Feb 25. PMID:23440925 doi:http://dx.doi.org/10.1002/anie.201209021

Contents


4i9d, resolution 1.70Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools