4idl

From Proteopedia

Jump to: navigation, search

Low melting temperature Anti-Cholera Toxin Llama VHH domain

Structural highlights

4idl is a 1 chain structure with sequence from Lama glama. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.09Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Variable heavy domains derived from the heavy-chain-only antibodies found in camelids (V(H)H domains) are known for their thermal stability. Here, the structure of A9, an anti-cholera toxin V(H)H domain (K(d) = 77 +/- 5 nM) that has an unusually low melting temperature of 319.9 +/- 1.6 K, is reported. The CDR3 residues of A9 form a beta-hairpin that is directed away from the former V(H)-V(L) interfacial surface, exposing hydrophobic residues to the solvent. A DALI structural similarity search showed that this CDR3 conformation is uncommon.

Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain.,Legler PM, Zabetakis D, Anderson GP, Lam A, Hol WG, Goldman ER Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Feb 1;69(Pt 2):90-3. doi: , 10.1107/S1744309112050750. Epub 2013 Jan 26. PMID:23385744[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Loading citation details..
Citations
0 reviews cite this structure
Structural and mutational analysis of a monomeric and dimeric form of a single domain antibody with implications for protein misfolding.
George et al. (2014)
-1 more
0 other articles
No citations found

See Also

References

  1. ↑ Legler PM, Zabetakis D, Anderson GP, Lam A, Hol WG, Goldman ER. Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Feb 1;69(Pt 2):90-3. doi: , 10.1107/S1744309112050750. Epub 2013 Jan 26. PMID:23385744 doi:http://dx.doi.org/10.1107/S1744309112050750

Contents


PDB ID 4idl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/4idl"
Personal tools