Structural highlights
Function
PSTS_PSEAI Binds 1 inorganic phosphate per subunit, required for phosphate transport (By similarity). In virulent strain MDR25, which expresses very high levels of this protein, implicated in host cell adhesion; antibody fragments against this protein decrease adhesion to host cells and increase transepithelial resistance of human epithelial cell monolayers. High-phosphate-grown MDR25 strains form smooth colonies, express less PstS, more biofilm and are less lethal in mouse infection models than high-phosphate-grown rough colonies that express more PstS, less biofilm and are more lethal in mouse infection models; whether this is phenotype is due to PstS is unknown, however feeding mice with phosphate supplements protects them from lethality. The ability of PstS to bind phosphate may allow it to acquire phosphate from its host (PubMed:18282104).[UniProtKB:G3XDA8][1]
See Also
References
- ↑ Zaborina O, Holbrook C, Chen Y, Long J, Zaborin A, Morozova I, Fernandez H, Wang Y, Turner JR, Alverdy JC. Structure-function aspects of PstS in multi-drug-resistant Pseudomonas aeruginosa. PLoS Pathog. 2008 Feb 8;4(2):e43. PMID:18282104 doi:10.1371/journal.ppat.0040043
