Structural highlights
Function
SYCE3_MOUSE Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism.[1] [2]
References
- ↑ Hu T, Wang Z, Zeng F, Chen X, Gu Z, Zheng L, Tong Q. Expression pattern of testis-specific expressed gene 2 in cryptorchidism model and its role in apoptosis of spermatogenic cells. J Huazhong Univ Sci Technolog Med Sci. 2010 Apr;30(2):193-7. doi:, 10.1007/s11596-010-0212-3. Epub 2010 Apr 21. PMID:20407872 doi:http://dx.doi.org/10.1007/s11596-010-0212-3
- ↑ Schramm S, Fraune J, Naumann R, Hernandez-Hernandez A, Hoog C, Cooke HJ, Alsheimer M, Benavente R. A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility. PLoS Genet. 2011 May;7(5):e1002088. doi: 10.1371/journal.pgen.1002088. Epub 2011 , May 26. PMID:21637789 doi:http://dx.doi.org/10.1371/journal.pgen.1002088
