4s2t

Structural highlights

Function

XPP_CAEEL Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:11606206, PubMed:25905034). Has activity towards the flp-9 neuropeptide KPSFVRF-amide (PubMed:11606206).^{[1] [2]}

See Also

• Aminopeptidase 3D structures

References

1. ↑ Laurent V, Brooks DR, Coates D, Isaac RE. Functional expression and characterization of the cytoplasmic aminopeptidase P of Caenorhabditis elegans. Eur J Biochem. 2001 Oct;268(20):5430-8. PMID:11606206 doi:10.1046/j.0014-2956.2001.02483.x
2. ↑ Iyer S, La-Borde PJ, Payne KA, Parsons MR, Turner AJ, Isaac RE, Acharya KR. Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site. FEBS Open Bio. 2015 Apr 2;5:292-302. doi: 10.1016/j.fob.2015.03.013. eCollection , 2015. PMID:25905034 doi:http://dx.doi.org/10.1016/j.fob.2015.03.013